Images of kratom products purchased at a “smoke shop” in suburban Chicago. The images show chopped leaves (A), which are typically brewed into “kratom tea”, capsules containing finely chopped leaves (B), and compressed tablets containing leaves or resin (C). Mitragynine is an indole-based opioid-receptor agonist and the most abundant active alkaloid in the plant Mitragyna speciosa, commonly known as kratom and biak-biak. Dry kratom leaf contains roughly 1.2–2.1% mitragynine. Pharmacology. Mitragynine itself acts primarily via μ-opioid receptors, though its oxidation product mitragynine pseudoindoxyl acts as a selective μ-opioid agonist with. For recreational drug users looking for an opioidlike high without the legal problems of heroin, fentanyl, and oxycodone, the Southeast Asian plant called kratom (Mitragyna speciosa) has provided. Kratom acts on the Cannabinoid receptors! Close. 183. Posted by. u/thekevlardonair. 1 month ago. Kratom acts on the Cannabinoid receptors! Recent research has shown that kratom has an effect on the Cannabinoid system in mammals, this could go a long ways towards explaining why kratom is so much more effective for neuralgias (nerve pain disorders) than are traditional opiates. It could also. Research shows that kratom is similar to morphine and other opiates in the way that it affects the brain. It acts as an opioid receptor agonist and mimics the structure of endogenous endorphins found in the body. These endorphins are naturally released in the body as a response to pain, orgasm, excitement, or rigorous physical exertion. Both. Home; News Analysis; FDA Declares Kratom an Opioid. We’re Here to Explain What It Does. The Scientist speaks with a clinical toxicologist to discuss how the supplement acts in the brain and what the agency's declaration means for research. Inside the body, kratom acts like an endorphin that stimulates opioid receptor agonism, but without forging the damaging, long-term relationships that opiates do. In this way, it is able to bring the body and mind important relief for real health issues, but with no risk of physical opiate addiction. This is a key difference. Mitragyna speciosa (commonly known as kratom) is a tropical evergreen tree in the coffee family native to Southeast Asia. M. speciosa is indigenous to Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, where it has been used in traditional medicines since at least the nineteenth century.