Kratom might decrease how quickly the liver breaks down some medications. Taking kratom along with some medications that are changed by the liver might increase the effects and side effects of these medications. Before taking kratom, talk to your healthcare provider if you take any medications that are changed by the liver. Kratom addiction and chronic use has led to cases of psychosis with hallucinations, delusion, and confusion. High-dose use may lead to fast heart rate (tachycardia) and low blood pressure (hypotension). Tremor, anorexia and weight loss are other possible side effects with long-term use. Once the effects of Kratom are gone, a spike in blood pressure is seen. This means that Kratom acts to reduce the blood pressure. Other users claim that Kratom doesn’t affect the blood pressure. One user stated that he works at a hospital and regularly checks his blood pressure and he has never noticed any change in his blood pressure. Read user ratings and reviews for KRATOM on WebMD including side effects and interactions, treatment effectiveness, ease of use, safety and satisfaction. Kratom Side Effects There are many positive Kratom effects, but one much use it in the right way to prevent side effects. This plant is not considered dangerous and there is a low risk of serious side effects or addictive potential. Unlike what the media reports suggest, no one in the USA has ever died from using Kratom and you will not likely. Like all other so-called drugs, kratom can have adverse effects, especially in those who are already on a medical regimen. With that being said, let’s talk about what we know about kratom and blood pressure. Learn more about Kratom uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Kratom Side Effects. There are several side effects associated with kratom use that range in severity from inconvenient to dangerous. Like the sought-after effects listed above, it's side effects are dependent on the dose taken and are similar to those found both for stimulant drugs and opiates, including: Pupillary constriction (tiny pupils).