Learn more about Kratom uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Kratom I take the prescription medication Seroquel and I am wondering if there are any interactions with Seroquel and Kratom. I read that kratom has interactions with mao inhibitors, and I am pretty sure that seroquel is not an maoi but I haven't found a straight answer. Some people use Seroquel to get high or to calm themselves after using stimulants. Whether using this drug alone or with other substances, an overdose is possible. It is important to know what an overdose looks like and how to help. Kratom Side Effects & Adverse Reactions (List of Possibilities) Just because kratom is “natural,” unregulated, and an herbal supplement does not mean that it’s somehow incapable of provoking side effects. Although many individuals tolerate kratom well without side effects and/or adverse reactions, it is important to emphasize the fact. Kratom is a pretty mild herb really especially in doses where you aren't looking to get high. There is central nervous system depression going on with those drugs absolutely, and it's generally a bad idea to combine those types of drugs, but I would think that adding Kratom to what you're taking there isn't likely to significantly increase that. Kratom isn’t currently an illegal substance, and has been easy to order on the Internet in recent years. In spite of its easy availability, however, we’re still learning about kratom’s effects on a person’s brain and body. Here are some things we know about kratom—and just as important, what isn’t known yet. What’s known about it Seroquel seems to prevent that from happening. But the same basic kratom euphoria still comes through well each time. I will mention though that Seroquel seems to greatly reduce cravings for kratom. I.e., usually when I first wake up I dive right at the bag of kratom, to get my morning 'eye opener'. But not so much since being on Seroquel. I. Kratom, the original name used in Thailand, is a member of the Rubiaceae family. Other members of the Rubiaceae family include coffee and gardenia. The leaves of kratom are consumed either by chewing, or by drying and smoking, putting into capsules, tablets or extract, or by boiling into a tea. The effects are unique in that stimulation occurs. We have hundreds of years of human use to show that kratom is safe. And, as more patients try kratom and their doctors see the results they’re getting, medical science could begin to compile documentation showing kratom’s efficacy in many conditions, such as Bipolar Disorder. But — when there’s no profit in it — will they? i restarted taking very low dose of seroquel mostly for sleep (25mg instant release) every night. I dose kratom just after waking up or after work ~5 hour before my seroquel dose and it never interacted with my dose or giving me more side effect! I would still talk to your doc before because even if i dont have problem with a low dose of the.